Controlling complexity and water penetration in functional de novo protein design
نویسندگان
چکیده
منابع مشابه
Controlling complexity and water penetration in functional de novo protein design.
Natural proteins are complex, and the engineering elements that support function and catalysis are obscure. Simplified synthetic protein scaffolds offer a means to avoid such complexity, learn the underlying principles behind the assembly of function and render the modular assembly of enzymatic function a tangible reality. A key feature of such protein design is the control and exclusion of wat...
متن کاملProtein architecture by de novo design
De novo protein design is an essential approach to elucidate the principles of protein structure and has potential applications that can yield novel molecules for medical and industrial purposes, such as drug discovery. The new idea that we can design artificial amino-acid sequences capable of folding into the desired three-dimensional (3D) structure may originate from the conceptual proposal m...
متن کاملTemplate assisted protein de novo design
The ultimate goal in protein de novo design is the Construction of artificial proteins exhibiting tailor-made structural and functional properties. To create nativelike macromolecules in copying nature's way has proven to be difficult because the mechanism of folding in its complexity has yet to be unravelled. In the present review we describe a conceptually different approach in protein design...
متن کاملDe novo backbone scaffolds for protein design
In recent years, there have been significant advances in the field of computational protein design including the successful computational design of enzymes based on backbone scaffolds from experimentally solved structures. It is likely that large-scale sampling of protein backbone conformations will become necessary as further progress is made on more complicated systems. Removing the constrain...
متن کاملDe novo protein design using pairwise potentials and a genetic
One of the major goals of molecular biology is to understand how protein chains fold into a unique 3-dimensional structure. Given this knowledge, perhaps the most exciting prospect will be the possibility of designing new proteins to perform designated tasks, an application that could prove to be of great importance in medicine and biotechnology. It is possible that effective protein design may...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2008
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0361106